JEUVEAU
by Evolus

​How does Jeuveau® work?

When injected, Jeuveau® temporarily prevents your nerves from telling your facial muscles to flex. 

​​In clinical trials, Jeuveau® was shown to temporarily improve the appearance of moderate to severe frown lines. In US studies, 68% and 70% of Jeuveau® patients had a 2-grade or better physician and patient-rated improvement in frown lines at Day 30.

In a study conducted in Europe and Canada, 54% of patients had visible results as early as 2 days after treatment. And at 5 months after treatment, 38% of patients had visible results with Jeuveau®

54% of patients had a ≥1-grade improvement in frown lines at Day 2 based on physician assessment compared to 12% for placebo (secondary endpoint). In US studies, 46% and 56% had a ≥1-grade improvement in frown lines at Day 2 based on physician-assessment compared to 8% and 17% for placebo (exploratory endpoint).

38% of patients had a ≥1-grade improvement in frown lines at 5 months based on physician assessment compared to 8% for placebo (secondary endpoint). In US studies, almost 5% of patients had a ≥2-grade improvement in frown lines at 5 months based on both patient and physician assessments compared to 0% for placebo (secondary endpoint).

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How to prepare for Jeuveau® injection?

Prior to treatment avoid any substances that may increase bleeding. The patients are advised to avoid aspirin, nonsteroidal anti-inflammatory drugs (NSAIDS), high-doses of vitamin E, fish oil, and alcohol for at least 2-3 days prior to injection to prevent prolonged bleeding and minimize bruising. Removing make up before an appointment can assist in visualizing blood vessels to help avoid bruising.

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What should I tell my provider before getting treatment with Jeuveau®?​

​​​Tell your healthcare provider about all your muscle or nerve conditions, such as ALS or Lou Gehrig’s disease, Myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects

Tell your healthcare provider about all your medical conditions, including: any side effects from botulinum toxin products, including dry eye; breathing, swallowing, bleeding, or heart problems; plans to have surgery; weakness of forehead muscles; drooping eyelids; have had surgery on your face; are pregnant or breastfeeding or plan to become pregnant or breastfeed (it is not known if Jeuveau can harm your unborn baby or passes into breast milk).

Especially tell your healthcare provider if you: have received any other botulinum toxin product in the past and the last 4 months, and exactly which product you received (such as BOTOX, BOTOX Cosmetic, MYOBLOC, DYSPORT, XEOMIN, or DAXXIFY).

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What are the possible side effects of Jeuveau®?

No serious or drug-related adverse events were observed in the Jeuveau® studies. However, it is still possible to develop side effects.

Get medical help right away if you have any of these problems any time (hours to weeks) after injection of Jeuveau®:

• Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.

• Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.

Other side effects may include:

• Localized pain, infection, inflammation, tenderness, swelling, erythema, and/or bleeding/bruising may be associated with the injection.

• Allergic reactions such as itching, rash, red itchy welts, wheezing, trouble breathing, asthma symptoms, or dizziness or feeling faint. Tell your healthcare provider or get emergency medical help right away if you develop wheezing or trouble breathing, or if you feel dizzy or faint.

• Heart problems. Irregular heartbeat and heart attack that have caused death, have happened in some people who received botulinum toxin products.

• Eye problems such as dry eye, reduced blinking, and corneal problems. Tell your healthcare provider if you develop eye pain or irritation, sensitivity to light, or changes in your vision.

The most common side effects of Jeuveau® include headache, eyelid drooping, upper respiratory infection, and increased white blood cell count.

These are not all the possible side effects of Jeuveau®. Call your doctor for medical advice about side effects. You may report side effects to FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

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